The Cyclosporine, Trough Level (C0), Whole Blood EDTA Test measures the lowest concentration of cyclosporine in the blood before the next dose. Cyclosporine is an immunosuppressant drug critical for preventing organ rejection in transplant patients and managing autoimmune disorders such as rheumatoid arthritis or Crohn’s disease. This test is vital to ensuring the correct dose is administered for optimal therapeutic effects, reducing the risk of drug toxicity or underdosing.

Monitoring cyclosporine levels is essential for: Excessive Levels (Toxicity): Symptoms may include nausea, vomiting, tremors, jaundice, and swelling. Can cause organ damage or kidney dysfunction. Decreased Levels (Subtherapeutic): Increased risk of organ rejection or poor disease management. Factors Affecting Cyclosporine Levels: Absorption variability among individuals. Interaction with certain foods or medications. Differences between brands or formulations of cyclosporine.

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